12/3/2023 0 Comments Blueprint pharmaOver the last year, we have established AYVAKIT as the standard of care in patients who are being actively treated for their advanced SM, and we are now focusing on increasing treatment rates in patients with SM and an associated hematologic neoplasm, where there has been lower adoption. "In addition, today we are reaffirming total revenue guidance for full-year 2022, while we lower product revenue guidance based on performance in the third quarter and our near-term expectations for growth. We plan to achieve this scale with the potential launch of AYVAKIT in non-advanced SM, multiple advancing clinical development programs for EGFR-mutant lung cancer and CDK2-vulnerable breast cancer, and an expansive precision therapy research pipeline, all of which build on our R&D achievements to date and leverage our fully integrated global infrastructure." "This morning at our Investor Day, we will highlight our 2027 Blueprint strategy to double our impact in five years across multiple metrics of portfolio strength. "The opportunity to bring AYVAKIT to patients with non-advanced SM, based on the positive results of the PIONEER study, will enable us to scale our impact and address the needs of a significantly larger patient population in the near term," said Kate Haviland, Chief Executive Officer of Blueprint Medicines. The company plans to highlight this business strategy, including commercial plans to bring AYVAKIT to patients with non-advanced systemic mastocytosis (SM), at its Investor Day event today. In addition, Blueprint Medicines today reported financial results and provided a business update for the third quarter ended September 30, 2022. 1, 2022 /PRNewswire/ - Blueprint Medicines (NASDAQ: BPMC) today announced its 2027 Blueprint to achieve precision medicine at scale, a five-year business strategy to expand the company's reach to broader patient populations by leveraging its scientific leadership, proven development capability and integrated business. Blueprint Medicines to webcast Investor Day 2022 event today at 8:30 a.m. Expects to achieve the high-end of total revenue guidance of $180 million to $200 million for full-year 2022. Reports updated data from the SYMPHONY trial of BLU-945 demonstrating clinical activity and a differentiated safety profile, supporting combination development in first-line EGFR-mutant non-small cell lung cancer. On track to submit supplemental new drug application for AYVAKIT® (avapritinib) in non-advanced SM in Q4 2022, with an anticipated U.S.
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12/3/2023 0 Comments Cowboy bebop netflix eden perkinsFollowing fan speculation that Radical Edward would not feature in the live-action adaptation, Netflix released footage showing Perkin's Radical Ed swaying in an alley before waving and disappearing. In the original anime, released in 1998, Radical Edward debuts in Episode 9, "Jamming with Edward." The character is presented as a 13-year-old hacker from Earth who helps Spike, Faye and Jet with an AI bounty. But it's such a cool costume." They also revealed that shooting Ed's scenes only took one night, terming the Cowboy Bebop set as "amazing." I’m so excited about people getting to know Ed. Cowboy Bebop fans were disappointed to hear that Radical Ed would not be a member of the crew in Netflixs live-action adaptation, but the character does. It's so spiky and I desperately want to touch it, but I don't because otherwise, it will mess it up. I play Taylor in rurangiofficial and Radical Ed in bebopnetflix :3 cowboy bebop is unlocked unlocked tomorrow at 7:00am NZST merlein appreciation post >. It's very free and movable, I suppose, which suits Ed very much. The latest Cowboy Bebop series on Netflix has taken many. "Getting into costume for the first time, it's so cool," Perkins continued. While Ed’s actor, Eden Perkins, is non-binary (they/them), they refer to Ed as she in an interview on the official aftershow. RELATED: The Bruce Lee Connection: How the Martial Arts Master Inspired Cowboy Bebop's Spike Spiegel Where's Edward Cowboy Bebop anime fans have been anxiously awaiting the debut of Radical Ed, who finally makes their grand debut in the closing moments of t. 12/3/2023 0 Comments Captain kidd deathAfter a few successes against small ships and a stopover in the Comoros Islands, in January 1698 he spotted a much larger ship rounding the tip of India. In early 1697, he steered a course for Madagascar. His tired and frustrated crew wanted pressured him to take more extreme measures – essentially, to turn pirate himself. He found few ships to attack, and some of his men were dying from illness. Kidd left New York in the Adventure Galley in September 1696, travelling first to Madeira and then Cape Verde, before heading south. His crew responded by turning their backs and slapping their backsides in disdain.Ī minor incident but, perhaps, a bad omen for the next and last time he would return to London, a few years later… The yacht then fired a shot at him to make him show some respect. Crucially, it also had two banks of oars – a rare addition, but one which made it much more manoeuvrable.Īs it set off down the Thames, Kidd for some reason failed to salute a Royal Naval yacht at Greenwich. It weighed over 280 tons, had 34 guns and was manned by 150 men. Kidd sold his old ship and commissioned a brand new one – the Adventure Galley. The cost of the venture was met by noble British lords, and Kidd was also given a letter of marque, essentially a licence to be a privateer, signed by King William III. In 1695, Kidd was asked by the Governor of New York to attack known pirates, along with enemy French ships. His role was as a privateer, someone engaged in maritime warfare, but a private person rather than a member of the Royal Navy. Over the next few years, Kidd fought for the British against the French and Spanish, capturing several ships. He and other crew members mutinied, took over the ship, and Kidd was made captain. In 1689, he joined a French-English pirate crew in the Caribbean. We don’t know much about his early life, but by the 1680s he was living in New York City, which the British had just taken over from the Dutch. Kidd was born in Dundee, Scotland, in 1654. But in the space of a few short years, he sailed all over the world, first chasing pirates, before crossing the line into piracy himself – or so it was claimed. Certainly, he went to the gallows protesting his innocence. Kidd attempted to barter for his life by offering in a letter - also in the exhibition - to reveal the location of a stash of treasure he had hidden away.He was one of the most famous figures of the Golden Age of Piracy, yet some maintain that William Kidd was never a pirate at all. The exhibition displays papers which Kidd claimed were vital for his defense against piracy charges but which mysteriously vanished before his trial and did not reappear until they surfaced in the National Archives in 1911. Museum of London curator Hillary Davidson says it was Kidd’s ultimate undoing. Her taking enraged the ruling Mogul who threatened to close down trade routes for good and thus jeopardized the position of the East India Company. The ship, which Kidd said was a legitimate prize because it was under French control, had an English captain and a cargo owned by Indians. In 1698, he took his greatest prize, the Quedah Merchant, a Moorish trading vessel from Armenia laden with gold, jewels, silver, silks, spices and guns. The Crown was supposed to get 10 percent of privateers’ pickings, but Kidd was accused of keeping most of the loot. Late in 1696, he attacked a British East India Company convoy and was branded a pirate. He left London in 1695 in the Adventure Galley, a 284-tonner with a crew of 150 and 34 cannon. His problems started when he took a government-backed private commission to clear the Indian Ocean of piracy. “The skull and crossbones may not have fluttered over ships in the Thames, but many of the pirates themselves were here at one time or another,” said Wareham, alluding to the fact that many seamen and women went crooked and turned pirate.Īn able and brave sea captain by all accounts, Kidd started his career in the Caribbean where he fought successful actions against the French. It ultimately asks whether Kidd was framed to save the reputation of the mighty East India Company and the Crown. Tom Wareham, curator of maritime history at the Museum of London in Docklands where the exhibition is being held, says the show explores how the line between privateering and piracy was often blurred. A privateer was a mercenary licensed by the King and the government to hunt merchant ships flying the colors of England’s enemies - then France and Spain. 12/3/2023 0 Comments Top tik tok videosUsing effects is a great way to spice up your TikTok content, and it can help you to gain more viewers too. This can be a great way to get noticed and divert traffic from larger accounts to your own videos. Try to make your comments eye-catching or funny and be sure to engage in conversations with anyone who responds to you. Be sure to comment consistently and authentically on every one of their videos. In order to make the most of this strategy, it’s a good idea to select 3-5 successful creators in your niche and follow them. However, if you’re having a hard time getting featured on the ForYou page, then it can be a good idea to comment on other TikTok videos in your niche as it will help you to engage with followers in that niche as well as like-minded creators. With so many creators posting regularly on TikTok, it can be hard to get noticed by engaged viewers in your niche. Be the first to comment on new videos from TikTok influencers in your niche Click here to activate your free account. Pallyy is a good option because they have a free plan that supports TikTok scheduling. Note: It’s easier to scale content with a social media scheduler. This strategy works particularly well for storytime videos. This keeps the audience engaged, and they then watch three clips instead of just one. You can also try splitting up your TikTok video into 2 or 3 parts. If you find yourself struggling with content ideas, consider taking inspiration from current trends. Instead of just posting once a day, consider posting 2-3 times a day to increase the number of chances you have to get views.Īlthough 2-3 videos a day may seem like a lot from a production standpoint, TikTok videos are fairly easy to produce, so keeping up with this content output is quite easy.Īlso, the more content you produce the better the chances are that one will go viral. This means that TikTok creators need to create more content too, in order to stay relevant. As TikTok is made up of much shorter clips, people consume much more content than they do on other video platforms. However, it’s particularly important on TikTok. Posting regularly on any social media platform is a must if you want to grow. We’re sharing everything from tips and best practices to little-known algorithm hacks. In this article, you will find 13 effective strategies for getting more views on TikTok. With over 732 million monthly active users, TikTok is brimming with new content, so it’s important to ensure that your videos stand out from the crowd if you want to get views. However, getting TikTok views can be tough. The fun and interactive platform is a great place to both consume and create content. In the last few years, TikTok has burst onto the scene and taken its place among the world’s most popular social media apps. Want to learn how to get views on TikTok? We’ve got you covered. 12/3/2023 0 Comments Commercial laundry cartWe can inspect your facility, identify sources of airborne contaminants, and recommend products from our line that will have the greatest impact on improving overall cleanliness levels. 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Our range of UV products includes disinfection solutions for every mode of transportation in your facility. The GP-16 by Granger is a laundry cart/material handling cart, commonly used in commercial laundry settings or in recycling centers. Energenics offers disinfection solutions that use hospital-grade processes suitable for the demanding environment of industrial healthcare linen facilities.Įnergenics has developed laundry-resistant versions of technologies used in other industries, which have been proven to reduce operational costs and increase disinfection outputs. To prevent contamination of clean linen during the processing of healthcare textiles, it is essential to thoroughly disinfect all surfaces that come into contact with the linen, from the finishing line to customer delivery. All Inclusive vacations in Thailand offer the luxurious break you’ve been dreaming of. Lured by the frenzy of Thailand’s capital? Check out our Bangkok Vacation Packages. 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I'd like to read an EB member's comment on this though since I of course have no insight into the plans for Shadowwalkers I don't really like to do this however since a vassal state has to pass all the money left at the end of the faction's turn to you - so you end with lots of money (even worse incase of a present money script) and your financial overview will be bugged then (even if you no longer have a vassal you'll see lots and lots of extra income that only "exists" in your financial screen but not in your treasury).Īnd furthermore I think that with the new government system of EB (which is because of the central/outlying authority system much more complex than in EBI) you will have a good base for RPing vassal states. (Still the MIITW AI has the same basic problems as the RTW AI (like diplomatic AI and military/strategic AI being independent from each other, leading to situations where you sign a truce and are attacked the same sethbest:Īs fas as I experienced in the mods I played (haven't played vanilla MIITW much, mainly because of the stackspamming and the inaccuracies) it is - compared to RTW - much more likely to convince an AI-controlled faction to become a vassal state. occupying for example, or paying tributes etc). It is true however that the AI still isn't really smart (although that depends a bit on how you define "smart") but you can change quite a few things and make for example alliances more stable or significantly increase the influence of certain actions (exterminating vs. This would result in the much more common diplomatic action of defeating a nation and then taking tribute and influencing their policies, rather than simply invading directly governing.Īnother option would be to have a campaign nation start as a vassal, and have to break free (plenty of examples but what comes to mind is Macedonia influenced by Hannibal ).Īnyways I hope to hear back if this is a reasonable possibility, or if its technically impossible.Īs far as I know diplomacy can't be modded.This is not exactly true, The King.Ĭheck out the "XAI" or "ReallyBadAI" subforums over at the twcenter - both managed to significantly change AI behaviour. I think it would add some realism to the game, being useful to exemplify the autonomy of regions of empires (I.E.- Rome in its control of frontier regions). I would love to see an actually useful implementation of vassal states in EB2, or another mod. Additionally I understand that diplomacy was not easily manageable in RTW, as far as controlling AI diplomacy anyways, is this different in MTW? I understand that in EB the government types fill the role of vassal cities. There has been one point that keeps coming to mind when playing EB, and other mods: generally the vassal state diplomatic actions are ignored. I've played through probably a dozen EB campaigns, as well as a few other mods, and check these forums and the twitter regularly just to keep track of my favorite mod, but I really never post (mostly because I don't really do forums, and because I would end up getting in innumerable arguments about interpretations of history). 12/2/2023 0 Comments 30 50 20 ruleThe 50/20/30 rule for budgeting simplifies how we manage our after-tax money to meet all of our financial goals.The 50/30/20 rule states that we take our after-tax income (our take-home pay) and allocate 50% to needs, 30% to wants, and 20% to savings. In the book, the plan focuses on the 50/30/20 rule and how it can simplify how we budget our money in a balanced and healthy way to pay all our bills, be aware of our spending habits, and still enjoy life. In 2006, Harvard Law Professor and Senator Elizabeth Warren and her daughter, Amelia Warren Tyagi, published their book: All Your Worth: The Ultimate Lifetime Money Plan, which changed the way we think about money and budgeting by introducing the 50/30/20 budget plan. It makes you wonder what you’re working for and if you’ll ever be able to enjoy life.įortunately, there’s another way. And we’re told to skip gift giving and vacations. We’re told to cut expenses to the bone, so we don’t overspend and to live modestly, which means no shopping, entertainment, or dining out. We’re told to obsessively track income, spending, and debts on a spreadsheet and not to spend a penny without reviewing it. We’ve all experienced budgeting advice that makes us want to give it all up and forget it. A simple solution to budgeting is known as the 50/30/20 rule and may forever change the way you feel about creating a budget. Despite the fact that many methods make it complicated and overwhelming, it doesn’t have to be. Managing our money effectively means having a good understanding of financial literacy, which is the knowledge and skills that allow us to use all our financial resources to make informed decisions about our financial life.Ī key component of financial literacy is budgeting our money. How does this compare to the 70/20/10 rule?. And it's during that eight hours of sleep that the brain then starts to clear away and remove all of that adenosine, all of that sleepiness chemical.ĪUBREY: And now you're ready to wake up. And after about 16 hours of being awake, there should be enough of that healthy sleepiness sort of swilling around within your brain - enough of what we call sleep pressure - to then make you feel ready to fall asleep and then stay asleep for eight hours.ĪUBREY: Is it really that direct? Is there really this compound that says, you are drowsy now?ĪUBREY: My biology is telling me to go to sleep. And the longer that you're awake, the more of that sleepiness chemical builds up in the brain. And that chemical is called adenosine, and it is the sleepiness chemical. WALKER: From the moment that everyone woke up this morning that's listening to this, a chemical started building up in your brain. One thing you need to know is you may not feel tired until 9 or 10 o'clock tonight, but your body started to prepare for sleep first thing this morning. But in this episode, we will focus on how your daytime habits influence your sleep. And in this episode, we've got five things for you to do today to help you sleep better tonight.ĪUBREY: There is plenty to be said about good nighttime routines for bed. And it turns out that process starts from the moment you wake up.ĪUBREY: This is your NPR LIFE KIT for getting better sleep. But scientists have also learned a lot about how to get those eight hours in and how to improve the quality of our sleep. Hook them with small testicles.ĪUBREY: So clearly, all kinds of things can happen to you if you don't get enough sleep. Testicles is probably one of the best hooks for maintaining people's attention.ĪUBREY: (Laughter) Yeah. It's the best opening that I've found yet. In addition.ĪUBREY: Oh, I'm sure that gets their attention. One of the first things I usually say in those speeches is regarding testicles - that men who sleep five to six hours a night have significantly smaller testicles than those. You know, for example, sometimes, I'll go and speak to a lot of Fortune 500 companies where there is a large dominance of sort of Type A males in the audience. WALKER: I think it's different facts for different populations. What is it that you've found over the years that really gets people's attention? He's a sleep researcher at UC Berkeley and the author of "Why We Sleep." He has made it his mission to convince the world that sleep is important. It's purely a selfish act on my behalf that I give myself that eight-hour sleep.ĪUBREY: That is sleep guru Matthew Walker. MATTHEW WALKER: If you understood the damage that insufficient sleep has on the brain and the body as I do, you would choose to do nothing else. Lack of sleep - it's linked to anxiety, depression, weight gain, Type 2 diabetes, even certain kinds of cancer. I'm a health reporter, and every week, I see a new study. You know the downside of not getting enough sleep? Let me tell you it is a scary long list. 12/2/2023 0 Comments Pictures of redacted filesWithout disclosing the source code of your own applications under the AGPL license. Data URIs provide a way to include a file, such as an image, inline by setting the src attribute of an img element as a Base64-encoded string using the. This doesn't mean the software is gratis!īuying a license is mandatory as soon as you develop commercial activitiesĭistributing the iText software inside your product or deploying it on a network You can also redact text, images, parts of images or drawings for. PdfSweep is dual licensed as AGPL/ Commercial software.ĪGPL is a free / open source software license. When making decisions to disclose signatures on public facing documents, agencies should keep in mind the purpose of the disclosure provisions in the GIPA Act. Remove content from your digital documents irretrievably instead of just covering it up. Especially when your images are Adobe Acrobat PDF files, the most common mistake is to redact by obscuring the text by drawing a black box over the text or images you want redacted. government censors blacked out documents that had already been released in full or redacted entirely different parts of the same document at different times. If the redaction isn’t burned into the image so that it cannot be removed, the redacted data can still be viewed. If you have an idea on how to improve pdfSweep and you want to submit code, Washington D.C., Ap The National Security Archive has published hundreds of examples over the years of dubious secrets where U.S. You can also build pdfSweep Community from source. First, the way the information is stored in an image file. ('A request that is overly broad and requires the public body to locate, review, redact and arrange for inspection of a vast quantity of material that is largely unnecessary to the appellants' purpose constitutes an undue burden.'). To answer it, we have to look at two things. But the answer could apply to photography as well, for example, if taking pictures in a war zone where recognizable faces could be dangerous for the subject. 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